Publications:

1. W. Liu*, E. Chun*, A.A. Thompson*, P. Chubukov, F. Xu, V. Katritch, G.W. Han, L.H. Heitman, A.P. IJzerman, V. Cherezov, and R.C. Stevens. (2012) Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions. Science. 337: 232-236.

2. J.W. Fairman, N. Dautin, D. Wojtowicz, W. Liu, N. Noinaj, T.J. Barnard, T.M. Przytycka, V. Cherezov, and S.K. Buchanan. (2012) β-domain structures of Escherichia coli O157:H7 Intimin and Yersinia pseudotuberculosis Invasin. Structure. 20:1233-1243

3. E. Chun*, A.A. Thompson*, W. Liu*, C.B. Roth, M.T. Griffith, V. Katritch, J. Kunken, F. Xu, V. Cherezov, L.H. Heitman, A.P. IJzerman, M.A. Hanson, and R.C. Stevens. (2012) New Fusion Partners for the Crystallization of G Protein-Coupled Receptors.Structure. 20: 967-976.

4. A.A. Thompson*, W. Liu*, E. Chun*, V. Katritch, H. Wu, E. Vardy, X-P Huang, C. Trapella, R. Guerrini, G. Calo, B.L. Roth, V. Cherezov, and R.C. Stevens. (2012) Structure of the Nociceptin/Orphanin FQ Receptor in Complex with a Peptide Mimetic. Nature. 485: 395-399.

5. H. Wu, D. Wacker, V. Katritch, M. Mileni, G.W. Han, E. Vardy, W. Liu, A.A. Thompson, X-P. Huang, F.I. Carroll, S.W. Mascarella, R.B. Westkaemper, P.D. Mosier, B.L. Roth, V. Cherezov, and R.C. Stevens. (2012) Structure of the human κ-opioid receptor in complex with JDTic. Nature. 485: 327-332.

6. J.S. Joseph, W. Liu, J. Kunken, T. Weiss and V. Cherezov. (2011) Characterization of lipid matrices for membrane protein crystallization by high-throughput small angle X-ray scattering. Methods. 55: 342-349.

7. T. Tiefenbrunn*, W. Liu*, Y. Chen, V. Katritch, D.C. Stout, J.A. Fee and V. Cherezov. (2011) High Resolution Structure of the ba3 Cytochrome c Oxidase from Thermus thermophilus in a Lipidic Environment. PLoS ONE. 6: e22348.

8. T. Shimamura, M. Shiroishi, S. Weyand, H. Tsujimoto, G. Winter, V. Katritch, R. Abagyan, V. Cherezov, W. Liu, G.W. Han, T. Kobayashi, R.C. Stevens and S. Iwata. (2011) Molecular basis of antihistamine specificity against Human Histamine H1 receptor. Nature. 475: 65-70.

9. F. Xu*, W. Liu*, M.A. Hanson, R.C. Stevens and V. Cherezov. (2011) Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases. Cryst. Growth Des. 11(4): 1193-1201.

10. W. Liu, and V. Cherezov. (2011) Crystallization of Membrane Proteins in Lipidic Mesophases. J Vis Exp. 49 (2011).

11. E. Chien, W. Liu, Q. Zhao, V. Katritch, G.W. Han, M.A. Hanson, L. Shi, A.H. Newman, J.A. Javitch, V. Cherezov, and R.C. Stevens. (2010) Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science. 330(6007): 1091-1095.

12. B. Wu, E. Chien, C. Mol, G. Fenalti, W. Liu, V. Katritch, R. Abagyan, A. Brooun, P. Wells, F. Bi, D. Hamel, P. Kuhn, T.M. Handel, V. Cherezov, and R.C. Stevens. (2010) Structures of the CXCR4 chemokine receptor in complex with small molecule and cyclic peptide antagonists. Science. 330(6007): 1066-1071.

13. W. Liu, M.A. Hanson, R.C. Stevens, and V. Cherezov. (2010) LCP-Tm: an Assay to Measure and Understand Stability of Membrane Proteins in a Membrane Environment. Biophys. J. 98(8): 1539-1548.

14. V. Cherezov, W. Liu, J. Derrick, B. Luan, A. Aksimentiev, V. Katritch, and M. Caffrey. (2008) In meso Crystal Structure and Computer Simulations Suggest an Alternative Proteoglycan Binding Site in the OpcA Outer Membrane Adhesin. Proteins. 71: 24-34.

15. V. Cherezov, E. Yamashita, W. Liu, M. Zhalnina, W.A. Cramer, and M. Caffrey. (2006) In Meso Structure of the Cobalamin Transporter, BtuB, at 1.95 Å Resolution. J. Mol. Biol. 364(4): 716-734.

16. W. Liu and M. Caffrey. (2006) Interactions of tryptophan, tryptophan peptides and tryptophan alkyl esters at curved membrane interfaces. Biochemistry. 45(39): 11713-11726.

17. W. Liu and M. Caffrey. (2005) Gramicidin Structure and Disposition in Highly Curved Membranes. J. Struct. Biol. 150(1): 23-40.

*indicates equal contribution of these authors

Conference Presentations:

• June 01, 2012 – Invited speaker for the 42nd Mid-Atlantic Macromolecular Crystallography Meeting. W. Liu. "Allosteric sites in the human A_2A adenosine receptor with 1.8 Å structure".

• Aug 16, 2011 – Invited speaker for the Public Forum Seminar at Novartis China. W. Liu. "New GPCR Structures and Structure Based Drug Design".

• May 20, 2011 – Oral presentation at the Cold Spring Harbor Asia Conference-Membrane Proteins: Structure & Function. W. Liu, F. Xu, E. Chien, B. Wu, T. Shimamura, R.C. Stevens and Vadim Cherezov. “Structure and Function of the GPCR Family”.

• Sep 16, 2010 – Oral presentation at the 13th International Conference on the Crystallization of Biological Macromolecules (ICCBM13). W. Liu, E. Chien, R.C. Stevens, and V. Cherezov. “Using LCP-FRAP to guide crystallization of GPCRs in lipidic mesophases”.

Poster Presentations:

• November 29, 2011 – Poster exhibition of JCIMPT-Complexes Scientific Advisory Board meeting. W. Liu, F. Xu, J. Liu, J.S. Joseph, R.C. Stevens and V. Cherezov. "LCP Technology Developments Contribute to New GPCR Structures".

• November 28, 2011 – Poster exhibition of the GPCR Network Scientific Advisory Board meeting. W. Liu, E. Chien, M.A. Hanson, R.C. Stevens and V. Cherezov. "Using LCP-FRAP to guide crystallization of Dopamine D3R in lipidic mesophases".

• May 18, 2011 – Poster exhibition of the Cold Spring Harbor Asia Conference-Membrane Proteins: Structure & Function. W. Liu, F. Xu, E. Chien, B. Wu, J.S. Joseph, R.C. Stevens and V. Cherezov. “Technology developments in LCP contribute to new GPCR structures”.

• November 17, 2010 – Poster exhibition of the 3rd NIH Roadmap Meeting on Membrane Protein Technologies. W. Liu, E. Chien, F. Xu, M.A. Hanson, R.C. Stevens, and V. Cherezov. “Using LCP-FRAP to guide crystallization of GPCRs in lipidic mesophases”.

• March 26, 2009 – Poster exhibition of the 2nd Annual NIH Roadmap Meeting on Membrane Protein Technologies. W. Liu, M.A. Hanson, R.C. Stevens, and V. Cherezov. “LCP Protein Thermal Stability Assay (LCP-Tm) to perform pre-crystallization analysis of Integral Membrane Proteins”.

• October 25, 2007 – Poster exhibition of The 65^th Annual Pittsburgh Diffraction Conference. W. Liu and M. Caffrey. "Interactions of tryptophan, tryptophan peptides and tryptophan alkyl esters at curved membrane interfaces".

• May 12, 2007 – Poster exhibition of IGP symposium at The Ohio State University. W. Liu and M. Caffrey. “Interactions of tryptophan, tryptophan peptides and tryptophan alkyl esters at curved membrane interfaces”.

• March 7, 2007 – Poster exhibition of 51^th Annual Meeting of the Biophysical Society. B. Luan, V. Cherezov, W. Liu, J. Moore, J. Derrick, M. Caffrey, and A. Aksimentiev. "Refining X-ray structures of the adhesin OpcA with molecular dynamics".

• October 11, 2005 – Poster exhibition of workshop on Biological Membranes --- Structure and Function at The Ohio State University. W. Liu and M. Caffrey. “Gramicidin Structure and Disposition in Highly Curved Membranes”..

• November 18, 2004 – Poster exhibition of Biophysics Program at The Ohio State University. W. Liu and M. Caffrey. “Gramicidin Structure and Disposition in Highly Curved Membranes”. .

Workshops:

• September 18, 2012 – LCP Tools and Technologies Workshop at Shanghai Institute of Materia Medica (SIMM). GO TO >>

• August 02, 2012 – LCP Tools and Technologies Workshop at Massachusetts Institute of Technology (MIT). GO TO >>

• June 02, 2012 – LCP Tools and Structure Determination Workshop at University of Virginia.

• November 16, 2010 – LCP Tools and Technologies Workshop at the Scripps Research Institute.